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Physiologic and allergenic characterisation of Alternaria alternata |
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Tuesday, 05 July 2005 |
The filamentous fungi Alternaria alternata is one of the most important allergenic moulds.
Great heterogeneity is often seen between mould extracts from different producers. These heterogeneities are mostly due to the inherent difficulties involved in the production of the mould raw material e.g. strain differences, cultivation conditions and harvested fraction. There are many studies investigating allergen expression in moulds. However, most of these studies lack a thorough physiological characterisation of the investigated strain thereby limiting the information and the possibilities of using it for direct process optimisation.
In an ongoing study we are performing a physiological characterisation of our A. alternata production strain. The aim of the investigation is to identify the critical physiological parameters influencing allergen expression during growth. Focusing on time-course experiments we are characterising the growth behaviour and allergen expression in order to be able to optimise and standardise our production process using a direct approach.
Contact Allergon for more information. |
